Estriol-3-glucosiduronate

Estriol glucosiduronate appears to be selectively retained in the amniotic fluid, probably because glucosiduronates are poorly transferred... 

Methytation of alcohols. Although alcohols alone are inert to diazomethane, they can be methylated efficiently by diazomethane under catalysis by boron trifluoride etherate or fluoroboric acid. A mineral acid cannot be used for catalysis because it itself reacts with the reagent, but a Lewis acid performs the function ascribed above to an organic acid. In investigating the structure of estriol D-glucosiduronic acid,... 

Hashimoto and Neeman (1963) have obtained pure crystalline estriol 16a-glucosiduronic acid from third trimester human pregnancy urine, completely characterized it and converted it to two derivatives. Infrared spectroscopy was used in the identification of these compounds, methyl(3,17/S-dimethoxyestra-l,3,5(10)-trien-16a-yl-2, 3, 4 -tri-0-methyl-)S-D-glucopyranosid) uronate, and methyl (3-methoxy-17/S-acetoxyestra-l,3,5(10)-trien-16a-yl-2, 3, 4 -tri-O-acetyl-)5-D-glucopyranosid)-uronate. 

The 100,000 g supernatant from guinea pig liver homogenate was used by IjCvitK et al. (1005) to biosynthesize estriol-3-suIfo-16-gluc< iduronate from the glucosiduronate in the presence of jVTP and magnesium sulfate. 

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