0-Glucosidase synthesis

MAL2 regulator of a-D-glucosidase synthesis some mutants are constitutive, others are non-utilizers 348-350... 

Maltose MALA MALS regulator of a-D-glucosidase synthesis constitutive for a-D-glucosidase synthesis and resistant to catabolite repression non-utilizing mutants have been found 348-351 349,352... 

Nojirimycin (247) inhibited protein synthesis and decreased the specific activity of y-glutamyltransferase in rat hepatoma cells [547]. It stimulated [5-glucosidase synthesis in Sporotrichum thermophile [548], and inhibited pulmonary colonization by B16-F10 murine melanoma cells [549],... 

The jS-D-glucosidase of Mucor racemosus was shown to be biosynthesized when the organism was grown in the presence of such diverse carbon sources as glycerol, lactate, o-xylose, o-ribose, methyl and phenyl a-o-glucopyrano-sides, maltose, and cellobiose. Enzyme biosynthesis was strongly repressed in the presence of hexoses and of adenosine 3, 5 -monophosphate. The role of adenosine 3, 5 -monophosphate in the control of jS-D-glucosidase synthesis in M. racemosus was discussed. 

In order to develop potent D-glucosidase inhibitors, a synthesis of carba-disaccharides containing valiolamine (205) was attempted by Horii and his coworkers utilizing method c. Coupling 205 with the 4-ketose 403, using NaBHjCN and hydrochloric acid, was effective in DMF, giving, after deprotection, the epimeric carba-disaccharides (404 and 405). The saturated... 

Synthesis of naturally occurring (J-D-glucopyranosides based on enzymatic P-glucosidation using -glucosidase from almond... 

Figure 25 Synthesis of naturally occuring phenylpropenoid (3-D-glucopyranosides. (a) allyl alcohol/immobilized (3-glucosidase with ENTP-4000, (b) Ac20/4-dimethylaminopyridine/pyridine, (c) organoboron reagents/Pd(OAcyCu(OAc)2/LiOAc/DMF, (d) K2C03/Me0H.

The synthesis of the imidazoline 122 was achieved from 121 by cleavage of the BOC group with TFA in dichloromethane followed by treatment of the salt with Et3N and eventually under hydrogen in the presence of Pd/C (Scheme 13). This compound showed poor biological activity on a-glucosidase (Scheme 14) <2000BMC135>. 

The convenient approach to analogs of the naturally occurring glucosidase inhibitor salacinol, was presented by Pinto.58 In a number of papers he described the synthesis of such derivatives. The general motif is shown in Fig. 42. 

Fleet GWJ, Nicholas SJ, Smith PW, Evans SV, Fellows LE, Nash RJ. (1985) Potent competitive inhibition of a-galactosidase and a-glucosidase activity by l,4-dideoxy-l,4-iminopentitols Synthesis of l,4-dideoxy-l,4-imino-D-lyxitol and of both enantiomers of l,4-dideoxy-l,4-iminoarabinitol. 

PHOSPHOGLUCOSE ISOMERASE Glucose-6-phosphate isomerase, PHOSPHOGLUCOISOMERASE D-Glucose 6-phosphate synthesis, 6-PHOSPHO-/3-GLUCOSIDASE GLUCOSE-1-PHOSPHATE URIDYLYLTRANS-FERASE... 

W. Hakamata, T. Nishio, and T. Oku, Synthesis of p-nitrophenyl 3- and 6-deoxy-a-D-glucopyrano-sides and their specificity to rice a-glucosidase, J. Appl. Glycosci., 46 (1999) 459—463. 

B. Shanmugasundaram and A. Vasella, Synthesis of new C(2)-substituted g/nco-configured tetrahy-droimidazopyridines and their evaluation as glucosidase inhibitors, Helv. Chim. Acta, 88 (2005)... 

K. Dax, V. Grassberger, and A. E. Stiitz, Simple synthesis of l,5,6-trideoxy-l,5-imino-D-glucitol, the first fluorine-containing derivative of glucosidase inhibitor 1-deoxynojirimycin, J. Carbohydr. Chem., 9 (1990) 903-908. 

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