Glucose transporter secondary structure

The structural features of the glucose transporter that determine its affinity for various sugars are poorly understood but arise from the differences in amino acid sequence which may impart differences in secondary or higher structure. One recent study has suggested that the intracellular C-terminus may determine the affinity for... 

The primary, secondary, and presumably tertiary, and higher, structure of the family of facilitative glucose transporters are similar. It is beginning to be understood which domains of these transporters are important for substrate and inhibitor binding and for subcellular localization. Future work will undoubtably uncover the molecular mechanism by which the facilitative transporters catalyze the translocation of sugars across the membrane. 

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