Glucose resonance spectroscopy

T. Nakada, I.L. Kwee, C.B. Conboy, Noninvasive in vivo denonstratlon of 2-fluoro-2-deoxy-D-glucose metabolism beyond the hexokinase reaction In rat-brain by F-19 nuclear-magnetic-resonance spectroscopy. J. Neurochem. 46 (1986) 198. 

Studies by electron-spin resonance spectroscopy showed that the reaction of hydroxy radicals with carbohydrates produces new radicals via hydrogen abstraction from a C-H group. When such carbohydrates as glucose are substrates, the H abstraction from a C-H bond is relatively nonselective, and all six possible radicals can be formed. The fate of these radicals is strongly influenced by the type of starting sugar and by the species present in the reaction medium. All of these aspects have been discussed in the review article by Sheldon et al.69... 

Seaquist ER, Tkac I, Damberg G, Thomas W, Gruetter R. Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy. Metabolism 2005, 54, 1008-1013. 

Lyon, R.C., Cohen, I.S., Faustino, PJ Megnin, F., Myers, C.E. (1988). Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res. 48,870-877. 

Haberg A, Qu H, Haraldseth O, Unsgard G, Sonnewald U (1998) In vivo injection of [1-13C]glucose and [l,2-13C]acetate combined with ex vivo 13C nuclear magnetic resonance spectroscopy a novel approach to the study of middle cerebral artery occlusion in the rat. J Cereb Blood How Metab 18 1223-1232... 

A feature of Horowitz and Gentili s work was the use of nuclear magnetic resonance spectroscopy. They showed that the 5 value for the benzylic proton [Hb in structure (7)], at C-1 of the D-glucose side-chain in vitexin, is virtually unchanged in the hepta-O-methyl and hepta-O-acetyl derivatives from this, it follows that the carbon atom which carries this proton cannot also carry a hydroxyl group (otherwise, acetylation would cause the signal to shift to much lower field, and methylation, to a higher field)... 

See also Atomic Absorption Spectrometry Principles and Instrumentation. Chiroptical Analysis. Chromatography Overview Principles. Clinical Analysis Glucose. Enzymes Enzyme-Based Electrodes. Food and Nutritional Analysis Overview. Infrared Spectroscopy Overview. Mass Spectrometry Overview. Nuclear Magnetic Resonance Spectroscopy Overview. Nuclear Magnetic Resonance Spectroscopy Applications Food. Optical Spectroscopy Detection Devices. Sampling Theory. Spectrophotometry Overview. Sweeteners. X-Ray Absorption and Diffraction Overview. 

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