Gluconeogenesis glucose 6-phosphate

Figure 26.2 Converting glucose 6-phosphate to glucose in gluconeogenesis. The ATP expended in glycolysis is not claimed back, helping the process to work uphill as well as downhill. ...

The main site of gluconeogenesis is the liver, and to a lesser extent the kidneys. The FA portions of triglycerides are converted to acetyl CoA in mitochondria and enter the citric acid cycle. The glycerol portion of triglyceride is converted to glycerol 3-phosphate and may be converted to glucose by gluconeogenesis. 

Glucose 6-phosphate is an important compound at the junction of several metabolic pathways (glycolysis, gluconeogenesis, the pentose phosphate pathway, glycogenosis, and glycogenolysis). In glycolysis, it is converted to fructose 6-phosphate by phosphohexose-isomerase, which involves an aldose-ketose isomerization. 

Glucose 6-phosphate to and from glycolysis and gluconeogenesis Glucose 6-phosphate to pentose phosphates (not reversible)... 

The interconversion of fructose-6-phosphate and fructose-1,6 bis phosphate is a control point in glycolysis and gluconeogenesis. Gluconeogenesis is a pathway which allows carbon atoms from substrates such as lactate, glycerol and some amino acids to be used for the synthesis of glucose, so it is in effect physiologically the opposite of... 

In addition to the common pathways, glycolysis and the TCA cycle, the liver is involved with the pentose phosphate pathway regulation of blood glucose concentration via glycogen turnover and gluconeogenesis interconversion of monosaccharides lipid syntheses lipoprotein formation ketogenesis bile acid and bile salt formation phase I and phase II reactions for detoxification of waste compounds haem synthesis and degradation synthesis of non-essential amino acids and urea synthesis. 

Two gluconeogenesis-specific phosphatases then successively cleave off the phosphate residues from fructose 1,6-bisphos-phate. In between these reactions lies the isomerization of fructose 6-phosphate to glucose 6-phosphate—another glycolytic reaction. 

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