Glucose metabolic pathways, model

Figure 1. Simplified three-compartment model of glucose metabolic pathways (51 ...

Katz and Rognstad (15) have more recently examined this problem and have developed a general and relatively simple model for glucose metabolism using this model and published data for labeling patterns of pentoses formed from glucose- C, they concluded that the net flow of carbon in the nonoxidative branch of the pentose phosphate pathway was from pentose to hexose, and that the net synthesis of pentose phosphates from hexose phosphates occurred exclusively by means of the oxidative branch of the pathway. 

The project was started with an existing model of metabolism in the cow, published and validated (Baldwin et al., 1987 referred to as Molly), which describes utilization of glucose, amino acids and fatty acids by muscle, adipose, visceral and mammary tissues at an aggregated metabolic pathway level. Elements of genetic background, response to nutritional environment and metabolic hormones are exphcitly embodied in equation forms and parameter values, such as maximal velocity, substrate sensitivity and control by anabolic and catabolic hormones. 

Glucose and glutamine, which provide carbon for catabolic and anabolic pathways, appear in the majority of models as limiting substrates. Certainly, the frequency of glucose and glutamine as limiting substrate indicates their importance to cell metabolism, but also the need for... 

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