Glucose electrode first generation

A. Karaykin, O. Gitelmacher, and E. Karaykina, Prussian blue-based first-generation biosensor. A sensitive amperometric electrode for glucose. Anal. Chem. 67, 2419—2423 (1995). 

The so-called first generation of glucose electrodes relies on monitoring either the consumption of oxygen or the formation of hydrogen peroxide ... 

Fig. 5. Schematic illustration of the three generations of glucose electrodes (A) first generation, (B) second generation, (C) third generation. E, enzyme.

A typical example of the first generation would be a glucose or lactate electrode comprising the appropriate oxidase entrapped in or bound to a membrane that is fixed at an oxygen or hydrogen peroxide detecting electrode and covered by a semipermeable membrane. 

Electrode configurations relying on determining either O2 or H2O2 (mainly glucose sensors) are termed first-generation (hio)sensors after the first and, at present, classical construction designed by Clark and Lyons [168]. 

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