Glucose counter-regulatory mechanisms

More importantly, IDDM patients have a defective glucose counterregulation. As Bolli and Perriello (1990) pointed out, counter-regulatory mechanisms in IDMM, compared with controls, are intact only in the first months after onset of diabetes. Thereafter, impaired insulin kinetics (due to... 

There has been some speculation that, with the chronic use of a fatty acid oxidation inhibitor, an impairment of exercise capacity and/or the counter-regulatory mechanisms involved in glucose homeostasis might occur. In normal [ 117] or streptozotocin-diabetic [118] rats, MeTDGA caused no decrease in the ability of the animals to perform strenuous or prolonged, moderately strenuous exercise. However, based on a reduced ability by tissues to use NEFA, one might expect that the ability to sustain exhaustive exercise would be reduced, particularly once glycogen levels had been depleted. 

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