Glucose cancer cell metabolization

Here, however, the emphasis will be on enzyme inhibitors per se, as they pertain to cancer cell metabolism — that is, inhibitors or blockers for certain critical biochemical reactions occurring in the conversion of glucose to pyruvic acid or pyruvate, and then to lactic acid or lactate. 

An Update on Inhibitors for Cancer Cell Metabolism Glucose to Lactic Acid... 

Kueck A, Opipari AWJr., Griffith KA, Tan L, Choi M, Huang J, Wahl H, Liu JR. 2007. Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol Oncol 107 450-457. 

Lyon, R.C., Cohen, I.S., Faustino, PJ Megnin, F., Myers, C.E. (1988). Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res. 48,870-877. 

A conclusion reached by Eigenbrodt et al. (1985) is that the metabolic behavior of tnmor (or cancer) cells differs from normal cells in that the forma show increased anaerobic glycolysis and glucose uptake, enhanced glutaminolysis enhanced nucleic acid (DNA) synthesis capacity, and enhanced lipid synthesis (p. 143). 

Simons AL, Ahmad IM, Mattson DM, Domfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res 2007 67 3364-3370. 

Y. W. Choi, and I. K. Lim, Sensitization of metformin -cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells. Cancer Lett., 346 (2014) 300-8. 

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