Glucose, aerobic oxidation enzyme complex

The reaction rate will be at a maximum at a certain pH, owing to complex acid-base equilibria such as acid dissociation between the substrate, the activated complex, and the products. Also, the maximum rate may depend on the ionic strength and on the type of buffer used. For example, the rate of aerobic oxidation of glucose in the presence of the enzyme glucose oxidase is maximum in an acetate buffer at pH 5.1, but in a phosphate buffer of the same pH, it is decreased. 

Under aerobic conditions and in the absence of high concentrations of glucose, yeast respires glucose. Under these circumstances pyruvic acid is oxidized and decarboxylated by the so-called pyruvate dehydrogenase complex. This system comprises three separate enzyme activities and is located within mitochondria. The three separate enzymes are pyruvate dehydrogenase, dihydrolipoyl transacetylase and dihydrolipoyl dehydrogenase (A, B and C in... 

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