Glucocorticosteroid receptors

Cadepond, F., Schweizeer, G.G., Segatd, M.I., Jibard, N., Hollenberg, S.M., Giguere, V., Evans, R.M., Baulieu, E. (1991). Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state. J. Biol. Chem. 266, 5834-5841. 

HFKBP51/52 Breast cancer Control of progestin and glucocorticosteroid receptor-mediated transcription 76... 

Glucocorticosteroids exert their effects by binding to glucocorticosteroid receptors, which are localized in the cytoplasm of target cells. There is only one single... 

Since high concentrations of glucocorticosteroid receptor mRNA have been reported in the alveolar walls, endothelium, and smooth muscle cells of bronchial and pulmonary vessels, these may be possible targets for steroidal anti-inflammatory drugs. 

Adcock IM, Lane SJ, Brown CR, et al. Abnormal glucocorticosteroid receptor-activator protein 1 interaction in steroid resistant asthma. J Exp Med 1995 182 1951-1958. 

Glucocorticoid Receptor-Glucocorticoid Resistance Glucocorticoids Glucocorticoids, Inhalable Glucocorticosteroids Gluco-mineralocorticoid Receptors Gluconeogenesis... 

Letrazole (Fig. 46.11) is a non-steroidal aromatase inhibitor that was approved for the treatment of postmenopausal women with hormone receptor-positive or hormone receptor-unknown, locally advanced or metastatic breast cancer. By binding to the heme group of aromatase, letrazole inhibits the aromatase and causes a reduction in plasma estrogen levels. Inhibition of aromatase by letrazole is competitive and highly specific, with no effect on enzymes that are responsible for the production of glucocorticosteroids and mineralocorticosteroids (160). 

All steroid hormones (estrogen, progestins, glucocorticosteroids and aldosterone) are now believed to exert their specific physiological action in a three step sequence binding to a specific cytosol receptor, transfer from cytosol to a specific nuclear receptor associated with chromatin, and modulation of gene expression in the target cell [184]. 

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