Glucocorticoids transcription factors

Ligand-bound corticosteroid receptors have been shown to interact to form heterodimers with other transcription factors, such as the jun protein. Such interactions are responsible for transactivation of the ds-regulatory sites known as AP-1 sites and for the glucocorticoid-mediated suppression of transcription, such as that seen in the pro-opiomelanocortin gene. A number of such specific protein interactions have been reported these interactions and their locations relative to other transcription factors transform a ubiquitous steroid hormone signal into a tissue-specific, graded cellular response. 

De Bosscher, K., Vanden Berghe, W., and Haegeman G., Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids Negative interference of activated glucocorticoid receptor with transcription factors, J. Neuroimmunol., 109, 16, 2000. 

Glucocorticoid Receptor and T-Cell-Specific Transcription Factors... 

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction. 

Salicylates additionally inhibit the transcription factor NFkb, hence the expression of proinflammatory proteins. This effect is shared with glucocorticoids (p. 248) and ibuprofen, but not with some other NSAIDs. 

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