Glucocorticoids central serous chorioretinopathy

Systemic glucocorticoid treatment can cause severe exacerbation of bullous exudative retinal detachment and lasting visual loss in some patients with idiopathic central serous chorioretinopathy (SEDA-20, 374 68). The atypical presentation of this condition can include peripheral retinal capillary nonperfusion and retinal neovascularization. The treatment of choice in patients with idiopathic central serous chorioretinopathy is laser photocoagulation. 

In a prospective, case-control study 38 consecutive patients (28 men and 10 women), aged 28-63 years with central serous chorioretinopathy, were compared with 38 age- and sex-matched controls (28 men and 10 women) aged 27-65 years (69). Eleven patients (29% eight men and three women) with central serous chorioretinopathy were taking glucocorticoids, compared with two patients (5.2% one man and one woman) in the control group (OR = 7.33, 95% Cl = 1.49, 36). 

Subtenon local injection of a glucocorticoid is effective in the treatment of certain forms of uveitis. Central serous chorioretinopathy, confirmed by optical coherence tomography, developed after a single local subtenon glucocorticoid injection to treat HLA-B27-associated iritis (70). 

Two patients developed central serous chorioretinopathy after prolonged treatment with glucocorticoids applied locally to the skin (427). 

Karadimas P, Bouzas EA. Glucocorticoid use represents a risk factor for central serous chorioretinopathy a prospective, case-control study. Graefe s Arch Clin Exp Ophthalmol 2004 242 800-2. 

Karadimas P, Kapetanios A, Bouzas EA. Central serous chorioretinopathy after local application of glucocorticoids for skin disorders. Arch Ophthalmol 2004 122 784-6. 

The two main adverse reactions to intravitreal inserts of sustained-release glucocorticoids are cataracts and increased intraocular pressure [31 ]. Glucocorticoids can also be associated with central serous chorioretinopathy or exacerbation of existing chorioretinopathy, a disorder that is characterized by serous detachment of the neurosensory retina at the posterior pole of the fundus. Central serous chorioretinopathy has been reported in a 42-year-old... 

---