Glucagon secretion, inhibition

In clinical studies, selective DPP-4 inhibition increased active circulating concentrations of GLP-1 and GEP by two- to threefold. This was associated with increased glucose-induced insulin secretion and suppression of glucagon secretion, although changes in satiety and gastric emptying have not been repotted. 

Factors that stimulate glucagon secretion include a decrease in blood glucose an increase in blood amino acids sympathetic nervous stimulation stress and exercise. Factors that inhibit glucagon secretion include insulin and an increase in blood glucose. Table 10.2 summarizes the major functions of the hormones discussed in this chapter. 

Nickel also may act to stimulate or inhibit the release of various hormones (Nielsen, 1971. 1972 Dormer et al., 1973 Clay, 1975 Harak-Sunderman, 1975). Nickel has been found to inhibit insulin release from the pancreas (Dormer et al.. 1973 Clay, 1975). and stimulates glucagon secretion (Horak-S underman, 1975). 

Somatostatin Polypeptide (14 residues) Inhibits gastrin secretion inhibits glucagon secretion... 

Gaxlric inhibitory peptide (GIP) is a 43-amino-acid polypep-lidc isolated from the duodenum. Secretion of GIP into the blood is stimulated by food. The primary action of GIP is inhibition of gastric acid secretion. Other actions include stimulation of insulin and glucagon. secretion and. stimulation of intestinal secretion. ... 

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