Glucagon molecular weight

The biochemical mechanisms by which cAMP-dependent phosphorylation leads to enhanced IR-PTH release remain to be determined. It is of interest, however, that isoproterenol activates phosphorylation of proteins of similar molecular weight in the rat parotid gland (22), while glucagon stimulates phosphorylation of a protein of molecular weight 19,000 in calcitonin-secreting cultured cells from a medullary carcinoma of the rat thyroid (22) It is conceivable that in all three tissues, activation of exocytosis results from a cAMP-dependent phosphorylation of a critical cellular substrate. 

Hormones themselves may be proteins. Notable examples are the more well-known insulin and the lesser-known thyrotropin and somatotropin (the growth hormone), as well as the ovarian luteinizing hormone and the follicle-stimulating hormone. If of relatively low molecular weight, protein-type hormones are also known as peptides, or specifically as peptide hormones. Examples listed, as a matter of course, are adrenocorticotropin, antidiuretic hormone, glucagon, and calcitonin. (Generally speaking, a peptide is a molecule with fewer than 50 amino acids, and a protein has more than 50 amino adds. The acids are combined in myriad combinations or permutations.)... 

Tung, A.K. (1973). Biosynthesis of glucagon evidence for a possible high molecular weight biosynthetic intermediate. Harm. Met. Res., 5, 416-24. 

Glucagon. The molecular weight of glucagon in 3 )00. It consists of oik polypeptide chain with 29 amino acid residues, whose sequence is known. Phe s(M uence differs greatly from that of insulin. 

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