Glove box technique

Barton, C. J., 1963, "Glove Box Techniques," in H. B. Jonassen and A. Weissberger, eds., Technique of Inorganic Chemistry, Vol. 3, Wiley-lnterscience, New York, p. 259. This chapter stresses the containment of toxic materials and presents a large collection of references on the use of glove boxes. 

Glove box technique — A glove box is a device that enables to work with materials which are sensitive to atmospheric components, under inert atmosphere (Ar, N2, or dry air depending on need and reactivity of materials). 

The complexes described below are extremely air and moisture sensitive. Therefore, the syntheses are conducted under nitrogen with rigorous exclusion of air and water by using Schlenk, vacuum line, and glove box techniques. Caution. Tetrahydrofuran and toluene are harmful if inhaled or absorbed through the skin. They should be handled in a well-ventilated fume hood, and gloves should be worn. THF forms explosive peroxides only fresh, peroxide-free material should be distilled. Potassium hydride removed from oil suspension and KC Mej are pyrophoric they should be manipulated in an inert atmosphere only. The compound l,2-C2H l2 is heat and light sensitive, as well as sublimable. 

Oxophilicity - Ln complexes that do not contain 0-donors are often highly air and moisture sensitive as a result of their latent oxophilicity, hence Schlenk line and glove box techniques are required for manipulation. 

Many organometallics are air sensitive, so the development of techniques which permit synthesis and characterization in a vacuum or inert atmosphere are central to the field. Even though the manipulation of air-sensitive compounds has been successfully practiced for a long time, the techniques have undergone constant improvement. For convenience these may be classified as vacuum line, bench-top inert atmosphere, and glove box techniques but as shown in this book combinations of them are common. 

The complexes described below are extremely air and moisture sensitive. Therefore, the syntheses are conducted under nitrogen with rigorous exclusion of air and water by using Schlenk, vacuum-line, and glove-box techniques. ... 

Caution. Both lithium pentamethylcyclopentadienide and 1 are extremely air sensitive and should be handled using high-vacuum line and inert atmosphere glove box techniques. 

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