Gloriosa superba

Colchicine is a poisonous tricyclic tropane alkaloid from the autumn crocus (Colchicum autumnale) and gloriosa lily (Gloriosa superba). This alkaloid is a potent spindle fiber poison, preventing tubulin polymerization.25 Colchicine has been used as an effective anti-inflammatory drug in the treatment of gout and chronic myelocytic leukemia, but therapeutic effects are attainable at toxic or near toxic dosages. For this reason, colchicine and its analogs are primarily used as biochemical tools in the mechanistic study of new mitotic inhibitors. [Pg.17]

Gloriosa superba Linn, (corms) Liliaceae Colchicine (48)... [Pg.3]

Gloriosa superba (Liliaceae) poison of Medea of Colchis 18th century gout immortalized by artists William Hogarth James Gillray victims included Benjamin Franklin,... [Pg.388]

Colchicine is obtained from the autumn crocus, Col-chicum autumnale, or the glory lily, Gloriosa superba. C. autumnale was first introduced for the treatment of gouty arthritis in 1763 by Von Storck. [Pg.638]

As far back as 1915 Clewer and co-workers investigated the tubers of Gloriosa superba L. (Liliaceae) obtained from Sri Lanka for alkaloids... [Pg.82]

From the corms of Gloriosa superba, Santavy and co-workers (310a) isolated a material, m.p. 158-161°, [a] —162° (chloroform), which was designated Substance Gj. A basic alkaloid, m.p. 229-231°, designated Substance Gg, was isolated from the same source. Substance Hg, m.p. 183-185°, was reported in one paper (294) to be a constituent of the corms of C. avtumnale. No analytical data were presented, but evidence for a tropoloid ring was obtained. [Pg.279]

Colchicine is marketed in tablets used for treatment of gout and familial Mediterranean fever and is found in certain plants autumn crocus or meadow saffron (Colchicum autumnale) and glory lily Gloriosa superba). A colchicine overdose is ex-... [Pg.173]

Colchicum species, Merendera species, Gloriosa superba ... [Pg.480]

Gloriosa superba L. India and Africa Corms, seeds... [Pg.465]

Various biotic and abiotic elicitors have been used to increase colchicine production. Application of methyl jasmonate as a biotic elicitor in the media showed increase in growth of the root cultures of Gloriosa superba. Higher concentration of methyl jasmonate decreased growth but enhanced intracellular colchicine content of the root cultures. However, such treatments with methyl jasmonate did not release colchicine into the medium [22],... [Pg.471]

Sivakumar G, Krishnamurthy KV, Hahn EJ, Pack KY (2004) Enhanced in vitro production of colchicine in Gloriosa superba L. an emerging industrial medicinal crop in South India. J Hort Sci Biot 79 602-605... [Pg.477]

Ghosh B, Mukheijee M, Jha TB, Jha S (2002) Enhanced colchicines production in root cultures of Gloriosa superba by direct and indirect precursors of the biosynthetic pathway. Biotechnol Lett 24 231-234... [Pg.477]

Ghosh S, Ghosh B, Jha S (2006) Aluminium chloride enhances colchicine production in root cultures of Gloriosa superba. Biotechnol Lett 28 497-503... [Pg.477]

The antitumour activity of colchicine (XXXIIa), the major alkaloid of the autumn crocus, Colchicwn autumnale and the African climbing lily, Gloriosa superba, was first reported at the beginning of this century [136]. The elucidation of its structure was finally completed when the tropolone ring system... [Pg.23]

Colchicine, CgjHggOgN, was obtained from the seeds and conns of the autumn crocus, Colchicum autumncde L. (Liliacese), by Pelletier and Caventou, and has since been found in other Colchicum spp. and in numerous Liliaceous spp. In Gloriosa superba it occurs with two other alkaloids (a) or CggHggOgNg, leaflets, m.p. 177-8°, and... [Pg.336]

Alkaloid from the corms of Gloriosa superba (Liliaceae). O -De-Me [7336-34-7]. 3-Demethylcolchiceine. Alkaloid L5... [Pg.255]

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