Glomerulosa cells, adrenal gland

Silver is cleared from the system via the liver (Furchner et al. 1968 Scott and Hamilton 1950). Deposition of uncleared silver can occur along the renal glomerular basement membrane (Creasey and Moffat 1973 Danscher 1981 Ham and Tange 1972 Moffat and Creasey 1972) and mesangium (Day et al. 1976), and in the Kupffer cells and the sinusoid endothelium cells of the liver (Danscher 1981). Silver has also been detected intra- and extracellularly in the skin and mucosa of the tongue, in the chromaffin cells, cells of the zona glomerulosa, and zona fasciculata of the adrenal glands, and in the exocrine and endocrine sections of the pancreas (Danscher 1981). 

The 5-HT7 receptors also are expressed in the periphery, where their best characterized function is to mediate relaxation of vascular smooth muscle (397). In particular, 5-HT7 receptors are expressed throughout the gut (398) and stomach (399), as well as in vasculature (400,401). 5-HT7 receptors are also expressed in adrenal glomerulosa cells (402,403) and corneal epithelial cells (404). In the adrenal gland, 5-HT7 receptors stimulate the release of aldosterone from adrenal glomerulosa cells (402,403) by increasing cAMP levels. 

The adrenal gland appears to be one organ, but functionally it is two different organs. The inner core of the gland is the adrenal medulla. It is imder nervous control and secretes epinephrine (adrenaline) and norepinephrine (noradrenaline). The outer layer of the adrenal gland is the adrenal cortex. The cells of the adrenal cortex closest to the surface of the gland constitute the zona glomerulosa. These cells synthesize aldosterone and release it into the bloodstream. 

Vitamin A demonstrated in the liver and the adrenal gland of the rat by fluorescence method. A. Liver of a rat deficient in vitamin A. No fluorescence. B. Liver of a normal rat. Moderate amounts of vitamin A fluorescence are present in the Kupffer cells and at places in fine droplets at edges of liver cells. C. Liver of a rat made hyper-vitaminotic with vitamin A. Marked vitamin A fluorescence is seen in the Kupffer cells which have apparently proliferated. Moderate amounts of fluorescence in small lipoid droplets within the liver cells. />. Adrenal of a vitamin A-deficient rat. No fluorescence. E. Adrenal of a well-fed rat. Moderate amounts of vitamin A fluorescence are seen in the lipoid droplets of the zona fasciculata. F. Adrenal of a rat made hypervitaminotic with vitamin A. There is striking vitamin A fluorescence of the lipoid droplets of the fascicular layer. The lipoid droplets of the zona glomerulosa are free of vitamin A fluorescence. 

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