Globin gene cluster

Some of this differential expression is achieved by having different regions of chromatin available for transcription in cells from various tissues. For example, the DNA containing the P-globin gene cluster is in active chromatin in the reticulocyte but in inactive chromatin in muscle cells. All the factors involved in the determination of active chromatin have not been elucidated. The presence of nucleosomes and of complexes of histones and DNA (see Chapter 36) certainly provides a barrier against the ready association of transcription fac-... 

Razin SV, Petrov P, Hancock R (1991) Precise localization of the alpha-globin gene cluster within one of the 20- to 300-kilobase DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase 11 sites in vivo evidence that the fragments are DNA loops or domains. Proc Natl Acad Sci USA 88(19) 8515-8519... 

The human hemopexin gene has been cloned (38) and is located near the P-globin gene cluster on human chromosome 11 (39). The promoters of the human, rat, and mouse hemopexin genes have been cloned, and the human gene contains a liver specific element (40) and an interleukin-6 responsive element (41), consistent with the positive acute phase response ofhemopexin (33,34). 

What types of mutations are found within the hemoglobin /3-globin gene cluster ... 

Primate Libraries Constructed in Various Vectors and Genes Isolated from /J-Globin Gene Cluster... 

Restriction enzyme map of a-globin gene cluster and some of the deletions (indicated as dark lines). 

Restriction enzyme map of Filipino-type deletion in ot-globin gene cluster. 

Using one or a more of the DNA analysis tools described above, effective prenatal detection of various mutations in the P-globin gene cluster has beeu successfully achieved. Although geue therapy for geuetic diseases is in its infancy, hopefully the future will briug effective treatmeut options for patients affected with thalassemia. 

Other approaches provided additional information on isochorcs, (i) When the sequences of long genomic regions around the human a and 0 globin gene clusters became available. 

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