Glimepiride dosage

Hypoglycemia - If hypoglycemia occurs during up-titration of the dose or while maintained on therapy, a dosage reduction of the sulfonylurea component of rosiglitazone/glimepiride may be considered. 

Special populations - In elderly, debilitated, or malnourished patients, or patients with renal, hepatic, or adrenal insufficiency, the initial dosing, dose increments, and maintenance dosage of rosiglitazone/glimepiride should be conservative to avoid hypoglycemic reactions. 

In contrast with previous LTV spectrophotometric method, Khan et al. [17] reported first -derivative spectrophotometric method to determine glimepiride in pharmaceutical dosage form. In this method, formation of drug complex was carried out by reacting glimepiride in MeOH with 2,3,5-triphenyl-2H-tetrazolium chloride in NaOH 0.1 M as an alkaline media. This mixture was then heated at 60 2 °C for 60 min. Drug complex formed was showing maximum absorption at... 

For the purpose of studying dissolution of glimepiride, spectrophotometric method was utilized to measure release of glimepiride from pharmaceutical dosage form. In these studies, phosphate buffer solution pH 5.5 was used as the dissolution media as well as the solvent. Wavelength measurement was set at 226 nm [20-23]. 

Furthermore, two HPTLC methods for determination of glimepiride in pharmaceutical dosage form have been reported [26,27]. In the HPTLC method developed by Menon et al. [27], standard, sample, and internal... 

TABLE S.2 Summary of HPLC methods used to analyze glimepiride in bulk drug substance and pharmaceutical dosage form... 

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