Glidants starch

Starches remain a popular glidant, in particular those with the larger grain sizes such as potato starch, possibly because of their additional value as a disin-tegrant in the formulation. Concentrations up to 10% are common, but it should be appreciated that excess may result in exactly the opposite effect of that desired (i.e., flow properties may worsen). Talc is also widely used and has the advantage that it is superior to starches in minimizing any tendency for material to stick... 

Note Colloidal silica (glidant) and sodium starch glycolate (disin-tegrant) were fixed at 0.1% and 5%, respectively, in all batches. Source. Ref. 100. 

Glidant Aids powder flow properties during manufacture Colloidal silica, starch... 

Components and composition Example Deletion or partial deletion of ingredient —> color, flavor, or ink. Changes in excipients as % (w/w) of total < specified ranges8 Filler +5 Disintegrant Starch +3 Other +1 Binder +0.5 Lubricant Ca or Mg stearate +0.25 Other +1 Glidant Talc +1 Other +0.1 Film coat +1 Note total NGT 5%... 

Like lubricants, glidants are fine powders and may be required for tablet compression at high production speeds to improve the flow properties of the material into the die or during initial compression stages. They are added in the dry state immediately prior to compression and, by virtue of their low adhesive potential, reduce the friction between particles. Colloidal silica is popular, as are starches and talc. 

Tablet glidant Agent used in tablet and capsule formulations to improve flow properties of powder mixture Colloidal silica, corn starch, talc...

Starch has been used as a glidant, though relatively large amounts are required. The use of large amounts of starch has also aided the disintegration properties. 

---