Hypoglycaemia glibenclamide

Asplund K, Wiholm BE, Lithner F. Glibenclamide-asso-ciated hypoglycaemia a report on 57 cases. Diabetologia 1983 24(6) 412-7. 

Kennedy TD, Keat AC, Chester M, et al. Predisposing factors in fatal glibenclamide induced hypoglycaemia. Pract Diabetes 1988 5 217. 

Glimepiride is designed to be used once daily and to provoke less hypoglycaemia than glibenclamide. 

A review of 57 instances of hypoglycaemia associated with glibenclamide exists. Coma or disturbed consciousness was observed in 46 patients and in... 

Hypoglycaemic reactions may appear after acute and chronic sulphonylurea application. The incidence of hypoglycaemia was examined for two different periods (1960-1969 and 1975-1984) by Berger et al. (1986) and was shown to be constant and quite comparable with 0.22 versus 0.25 per 1000 patients per year. However, the risk was significantly higher with glibenclamide and... 

Data on relative safety suggest that chlorpropamide is the most toxic sulphonylurea (Ferner, 1988), but glyburide causes more dangerous hypoglycaemias than chlorpropamide. Glibenclamide has been shown to have a delayed effect on stimulating insulin secretion and this may be responsible for many unexpected severe hypoglycaemic episodes (Turner et al., 1987). 

No significant difference was seen in the calculated mortality risk for metformin-associated lactacidosis and glibenclamide-associated hypoglycaemia. Sulphonylureas were no less dangerous than metformin and both should be used with care in non-insulin-dependent diabetics, especially in elderly subjects and those with impaired renal or hepatic function (Campbell, 1985). 

Holstein A, Plaschke A, Egberts EH. Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide. Diabetes Metab Res Rev 2001 17(6) 467 73. 

Acebutolol appears to inhibit the effeets of glibenclamide, but has no effect on tolbutamide. Also, two isolated cases of hypoglycaemia have been seen with acebutolol, in one patient taking gliclazide and one patient taking chlorpropamide. ... 

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