Gliadel Wafer - Carmustine

Gliadel Wafer carmustine Gyne-Lotrimin clotrimazole... 

A commercial product based on polyanhydrides is Gliadel wafer containing carmustine, an antitumor agent. The wafer, 1.45 cm in diameter and 1 mm thick, is made of poly[bis-(/>carboxyphenoxy) propane sebacic acid] in an 80 20 molar ratio. 

Caprilon tranexamic acid carmustine Becenun, BiCNU, Carmubris, Gliadel Wafer, Nitrumon... 

Implantable delivery systems offer a number of advantages over more traditional delivery routes, particularly for biological macromolecules (including peptides, proteins, and oligonucleotides). Some specific delivery mechanisms to date include polymer depots (e.g., Gliadel Wafer, prolifeprosan 20 with carmustine implant) and osmotic pumps (e.g., Viadur leuprolide acetate implant). 

Westphal M, Hilt DC, Bortey E, Delavault P, Ohvares R, Warnke PC, Whittle IR, Jaaskelainen J, Ram Z. A phase 3 trial of local chemotherapoy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro-oncol 2003 5. 

While many different polymer chemistries have been developed for drug delivery applications, only one class of polymer beside the polyesters has received regulatory approval. Gliadel is a thin wafer containing the chemotherapeutic agent carmustine (BCNU) in a polyanhydride polymer matrix. Gliadel received... 

AdruciP - fluorouracil Gliadel- carmustine wafer (aldesleukin)... 

So far, polyanhydrides have only been approved by the FDA as a drug dehvery system commercially produced by Guilford. Chemotherapeutic agent BCNU (carmustine) loaded in poly(CPP-SA) 20 80 wafer (Gliadel ) was used for treating brain tumors [161,194,195], More applications in controlled release include eye disorder, local anesthetics, and anticoagulants [194], Further biocompatibility analyses need to be conducted for the use of polyanhydrides in other tissue engineering applications. 

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