Glassy pharmaceuticals amorphous drugs

Craig, D.Q.M., Royall, P.G., Kett, V.L., and Hopton, M.L. 1999. The relevance of the amorphous state to pharmaceutical dosage forms Glassy drugs and freeze dried systems. Int. J. Pharm. 179,... 

Pharmaceutical solids can generally be described as crystalline or amorphous (or glassy). In fact, the actual solid phase composition of a pharmaceutical formulation is usually characterized by an intermediate composition, both crystalline and amorphous in character. In a multicomponent system, such as a solid formulation comprising drug and excipient(s), certain components or even a single component may be... 

Many solid compounds are known to exist in different crystalline modifications such as amorphous, crystalline or glassy states affecting solubility, dissolution rate, stability and bioavailability. In order to improve the pharmaceutical potential, therefore, it is important to control the crystallization, the polymorphic transition, and whisker generation of solid drugs. ... 

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