Ghost Erythrocytes and Diffusion Constants

Several mechanisms are involved in the permeability through Caco-2 cells. In order to obtain a more pure measure of membrane permeability, an experimental method based on ghost erythrocytes (red blood cells which have been emptied of their intracellular content) and diffusion constant measurements using nuclear magnetic resonance (NMR) has been proposed [108]. 

Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics, Med. Res. Rev. 1996, 16, 243-266. 

Beaumont, K., Walker, D. K., Property-based design optimisation of drug absorption and pharmacokinetics, J. Med. Chem. 2001, 44, 1313-1333. 

3 Smith, D. A., Van de Waterbeemd, H., Walker, D. A., Pharmacokinetics and Metabolism in Drug Design, Wiley-VCH, Weinheim, 2001. 

4 Ajay, Walters, W. P., Murcko, M. A., Can we learn to distinguish between drug-like and nondrug-like molecules J. Med. Chem. 1998, 43, 3314— 3324. 

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