Genotyping repeats

In patients infected with non-genotype 1 HCV disease, check the HCV RNA level at the end of treatment (24 weeks). If HCV RNA is undetectable, continue treatment for another 24 weeks. Repeat the HCV RNA 24 weeks after completion of therapy to determine SVR.41... 

Genotyping of the TS Promoter Variable Tandem Repeat and Clinical Outcome... 

Yan L, Zhang S, Eiff B et al. Thiopurine methyltransferase polymorphic tandem repeat genotype-phenotype correlation analysis. Clin Pharmacol Ther 2000 68 210-219. 

La Spada, A. R., Roling, D. B., Harding, A. E. et al. Meiotic stability and genotype-phenotype correlation of the trinucleotide repeat in X-linked spinal and bulbar muscular atrophy. Nat. Genet. 2 301-304,1992. 

Harrod SB, Mactutus CF, et al (2004) Sex differences and repeated intravenous nicotine behavioral sensitization and dopamine receptors, Pharmacol Biochem Behav 78(3) 581-592 Hatchell PC, Collins AC (1980) The influence of genotype and sex on behavioral sensitivity to nicotine in mice. Psychopharmacology 71(1) 45 9 Henschke Cl, Miettinen OS (2004) Women s susceptibility to tobacco carcinogens. Lung Cancer 43(l) l-5... 

Spooner, D. M., Nunez, J., Trujillo, G., Herrera, M., del, R., Guzman, R, Ghislain, M. (2007). Extensive simple sequence repeat genotyping of potato landraces supports a major reevaluation of their gene pool structure and classification. Proc. Nat. Acad. Sci., 104,19398-19404. 

Several colorectal cancer studies have identified dilferences in TSER genotype between tumor and normal DNA. The frequency of the discrepancies range from 4% to 77.3% of TSER 2/ 3 heterozygotes [median 56% reviewed in (48)] and no allele bias is apparent (i.e., one repeat is not favored over the other). Curiously none of the studies have identified genotype discrepancies at a frequency of 15%, which would be consistent with the frequency of 18p loss of heterozygosity (LOH) in colorectal cancer. 

Landi, S., Ponzanelli, I., Hirvonen, A., Norppa, H. Barale, R. (1996b) Repeated analysis of sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes effect of glutathione S-transferase Tl and Ml genotype. Mutat. Res., 351, 79-85... 

De Benedictis et al., 1998 longevity. In particular, the frequency of 3 APOB-VNTR alleles with fewer than 35 repeats was significantly lower in cases than in controls. The frequency of SS (small, 26-34 repeats) in the genotype pool increased from the group aged 10-19 years (3.06) to that aged 40-49 years (8.51). Then it declined, reaching the minimum value in centenarians (1.58). 

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