Genomics high-throughput

The continuing quest for novel and safer drugs has led to the introduction of myriad new technologies within the pharmaceutical industry. Notably, advances in genomics, high-throughput screening, combinatorial chemistry. 

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B. Rupp, Struct. Genomics High Throughput Struct. Biol., 2006, 61—104. 

Structural genomics is the systematic effort to gain a complete structural description of a defined set of molecules, ultimately for an organism s entire proteome. Structural genomics projects apply X-ray crystallography and NMR spectroscopy in a high-throughput manner. 

The constantly increasing amount of data coming from high throughput experimental methods, from genome sequences, from functional- and structural genomics has given a rise to a need for computer-assisted methods to elucidate sequence-structure-function relationships. 

Structural genomics aims to use high-throughput structure determination and computational analysis to provide structures and/or 3D-models of every tractable protein. The intention is to determine as many protein structures as possible and to exploit the solved structures for the assignment of biological function to hypothetical proteins. 

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