High throughput structure

Structural genomics aims to use high-throughput structure determination and computational analysis to provide structures and/or 3D-models of every tractable protein. The intention is to determine as many protein structures as possible and to exploit the solved structures for the assignment of biological function to hypothetical proteins. 

Nonetheless, the speed and flexibility of this emerging technology could provide the key to meeting the demands of high-throughput structure determinations. 

Kuhn P, Wilson K, Patch MG, et al. The genesis of high-throughput structure-based drug discovery using protein crystallography. Curr Opin Chem Biol 2002 6 704-10. 

Lesley, S. A., Kuhn, P, Godzik, A., Deacon, A. M., Mathews, I., Kreusch, A., et al. (2002). Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc. Natl. Acad. Sci. USA 99,11664-11669. 

Molecular replacement techniques for high-throughput structure determination... 

FOCUSED LIBRARIES HIGH-THROUGHPUT STRUCTURE-ACTIVITY RELATIONSHIPS... 

D. B. Kassel, C. van Pelt, and K. Lim, Novel Analytical Strategies in Support of High Throughput Structural Chemistry, 51 ASMS Conference on Mass Spectrometry and Allied Topics, Book of Abstracts. 

While the PISA wheel patterns offer high throughput structure and... 

Steindl, T. M., Schuster, D., Wolber, G., Laggner, C., Langer, T. High-throughput structure-based pharmacophore modelling as a basis for successful parallel virtual screening. J. Comput.-Aided Mol. Des. 2006, 20, 703-715. 

Binkowski, T. A., Joachimiak, A., Liang, J. Protein surface analysis for function annotation in high-throughput structural genomics pipeline. Protein Sci. 2005, 14, 2972-2981. 

Kuroda, Y., K. Tani, Y. Matsuo, and S. Yokoyama. 2000. Automated search of natively folded protein fragments for high-throughput structure determination in structural genomics. Protein Sci 9 2313-21. 

Merrill AH, Jr., Sullards MC, Allegood JC, Kelly S, Wang E. Sphingolipidomics high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods 36(2005) 207-224. 

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