Genomic markers

Zhang, L.H., Chai, J.J., Jiao, W., Osman, Y. and McManus, D.P. (1998) Mitochondrial genomic markers confirm the presence of the camel strain (G6 genotype) of Echinococcus granulosus in north-western China. Parasitology 116, 29-33. 

The second section shows how genetic and genomic information is currently applied to treatment individualization and optimization Eleven chapters describe some of the most elegant examples of genetic and genomic markers that are predictive of the survival and toxicity risk of cancer patients. 

Figure 15-2 Schematic illustration of potential advantages of genomic biomarkers in a dosetime plot of toxicological study. Histopathology lesion is expected to occur when an animal is dosed between MTD (maximum tolerated dose) and NOEAL (no observed adverse effect level). The triangles and circles indicate where a biomarker can be detected or applied to indicate late injury. Genomic marker A is more predictive than clinical chemistry marker C because it can be detected earlier under the same dose treatment and is more sensitive as it works at a lower dose compared to another presumed clinical chemistry marker D.

Model for Simply Enhanced Genomic Marker TAT mRNA Induction by Corticosteroid Administration Developed by Ramakrishnan et al. JPP 29 1-24 (2002)... 

Some of the more spectacular uses of PCR include cloning of ancient DNA from extinct species such as the woolly mammoth ruling out suspects in criminal cases by forensic science, and providing genomic markers (STSs) in chromosome-mapping studies used in the Human Genome Project (see Chapter 21). 

McNamara D M (2004). Pharmacogenetics in heart failure Genomic markers of endothelial and neurohumoral function. Congest. Heart Failure. 10 302-308. 

Pennisi, E. (1998) Using the wildly popular genome markers called SNPs to track genes may be less straightforward than researchers expected. A closer look at SNPs suggests difficulties. Science 281,1787-1789. 

FIGURE 28.1 Physiogenomic analysis of gene marker ffequenqr as a function of phenotype variability (association a specific genomic marker is enriched selectively in the patients with a specific outcome). 

Bernard, C., I. Cassar-Malek and J.F. Hocquette, 2006. Genomic marker for meat tenderness. Patent 06 300943.5. 12 September 2006. 

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