Genomes, single

Fan JB, Surti U, Taillon-Miller P, Hsie L, Kennedy GC, Hoffner L, Ryder T, Mutch DG, Kwok PY. Paternal origins of complete hydatidiform moles proven by whole genome single-nucleotide polymorphism haplotyping. Genomics 2002 79 58-62. 

Taxonomy of Known Viral Structure RNA Genome, Single Negative-Sense Strand ... 

Taxonomy of Known Viral Structure DNA Genome, Single Stranded"... 

RNA genome double stranded, 142 RNA genome single negative-sense strand, 140-141... 

RNA genome single positive-sense strand, 133-138, 139, 152 RNA genome single stranded, 143—144 satellite viruses and, 139-141, 139 Virion stabilization, 411 Virus (es), 37... 

It is not necessary and would be enormously expensive to obtain a person s entire genome. Single-nudeotide polymorphisms (SNPs snips) are specific DNA sequences. Single nucleotides—A, T, C, or G—are what make up the genes. For example, two DNA sequences, such as AAGCCTAoi AAGCTTA, differ only in a single nucleotide. 

The most prominent feature of cytocidal virus-cell interaction is the inhibition of host macromolecular synthesis. The understanding of the molecular basis of this inhibition where the host DNA, RNA, and protein synthesis is selectively blocked while virus replication goes on is the central theme of this chapter. The mechanisms by which particular virus-cell combinations accomplish this inhibition appear to be quite variable, and a number of hypotheses have been proposed to explain this phenomenon. It has been suggested that inhibition of host macromolecular synthesis by cytocidal viruses may be initiated by (1) structural components of the input virion, (2) virus-induced products synthesized in the course of infection, (3) viral nucleic acids as either replicative intermediates (double-stranded RNA) or as multiple copies of the viral genome (single-stranded RNA), or (4) the results of perturbations of the cellular membrane which allow for changes in the normal ion concentrations within the cell. 

Williams J G K 1997 Single-molecule detection of specific nucleic acid sequences in unamplified genomic DNA Anal. Chem. 69 3915-20... 

Chromosome Discrete unit of the genome consisting of a single molecule of DNA that carrit many genes. 

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