Genome analysis single-nucleotide polymorphisms

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Wong KK, Tsang YT, Shen J et al. Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res 2004 32 e69. 

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With the recent automation and miniaturization of DNA typing methods, the analysis of polymorphism began to revisit the single nucleotide polymorphism analysis (SNPs), another form of loci polymorphism. They were first described about in the 1980s, but only recently are being studied for paternity analysis. They are abundant in the genome and perceived as being more stable than STRs due to lower mutation rates. 

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