Genome, human determination

Guccione, E. et al. (2006) Myc-binding-site recognition in the human genome is determined by chromatin context. Nature Cell Biology, 8, 764—770. 

Finally, with all the great strides being made to unravel the human genome and determine the gene structures and their influence, we are much nearer to tailoring drugs to match male and female differences, and with enhanced computer power, this chapter may become moot. 

HK-2 cells (Human Kidney 2) (ATCC CRL-2190) are a human derived cell line immortalized by transduction with human papilloma virus 16 (HPV-16) E6/E7 genes [109], The E6/E7 genes are present in the HK-2 genome as determined by PCR. The cells retained a phenotype indicative of a differentiated proximal tubule cells, although confluent HK-2 monolayers do not form domes and generate only a weak transient TEER of 20 2.cm2 [110]. However, it was shown that barrier function could be... 

Advances in biochemical knowledge have illuminated many areas of medicine. Conversely, the study of diseases has often revealed previously unsuspected aspects of biochemistry. The determination of the sequence of the human genome, nearly complete, will have a great impact on all areas of biology, including biochemistry, bioinformatics, and biotechnology. 

DETERMINATION OF THE SEQUENCE OF THE HUMAN GENOME HAS PRODUCED A WEALTH OF NEW FINDINGS... 

Determination of the complete sequence of the human genome, now almost completed, is one of the most significant scientific achievements of all time. 

The promise of being able to predict and modify the genetic characteristics of an organism fuelled massive efforts to determine the base sequences of human genes. The human genome project has now reached the goal of sequencing all the important DNA carried by humans. 

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