Genome Features and Organization

The proteome is defined as the total proteins encoded by the genome of an organism. Proteomics is the science of describing the identification and features of the proteome of an organism. 

The chromosomal arrangement of genes responsible for PG synthesis in M. tuberculosis is similar to that in other bacteria, and based on the similarity of the basic structure, comparison of genome sequence, and direct investigations, it can reasonably be assumed that the mycobacterial PG biosynthetic pathway is similar to that of E. coli with the exception of additional enzymatic steps, which introduce the distinguishing features noted above (Figure 3). There are excellent reviews on this subject in other organisms and these should be applicable to mycobacteria. 

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