Genetic therapy

Matskevich AA, Cordelier P, Strayer DS (2003) Conditional expression of IFN-alpha and IFN-gamma activated by HBV as genetic therapy for hepatitis B, J Interferon Cytokine Res 23 709-721... 

BGTD Biologies and Genetic Therapies Directorate (Canada)... 

At this time no effort is being made to alter the DNA in human germ cells. It seems undesirable to experiment with such changes.1603 4623 However, as methods are developed for genetic therapy of somatic cells, we will rear more and more healthy carriers of serious genetic defects. Eventually we may need to develop therapy for germ cells. 

Problems have resulted from the availability of hormones and other products of genetic engineering. For example, should parents be allowed to request human growth hormone for short children who do not have a pituitary deficiency Should it be available to athletes and to aging people Use of stem cells in genetic therapy raises another set of questions. 

Wickstrom, E. (1998) Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors. Marcel Dekker, New York. 

Human fibroblasts - 2001 Shire Human Genetic Therapies Europe... 

Because the formation of a stable TBP-DNA complex is crucial for the expression of a wide variety of genes, it is imperative that the mechanism for its formation be understood. This is particularly timely now, as the rapid sequencing of genomes and the perspective of genetic therapy call for a deeper... 

Hospital products with the exception of those of genetic therapy or cell culture prepared on mediccil prescription in Pharmacopoeia indications in the absence of a specific pharmaceutical specicility and destined to be used by one or more patients in that establishment. 

Shire Human Genetic Therapies, Cambridge, Massachusetts... 

Sullenger BA. Targeted genetic repair An emerging approach to genetic therapy. J Clin Invest 2003 112 310-311. 

Chernajovsky Y, Dreja H, Daly G, Annenkov A, Gould D, Adams G, Croxford JL, Baker D, Podhajcer OL, Mageed RA (2000) Immuno- and genetic therapy in autoimmune diseases. Genes Immun, 1(5) 295-307. 

These properties make it difficult to excrete. Thousands of newborn babies are treated for jaimdice every year by prolonged irradiation with blue or white light which isomerizes 4Z,15Z bilirubin to forms that are more readily transported, metabolized, and excret-ed. A more difficult problem is posed by the fatal deficiency of the glucuronosyl transferase responsible for formation of bilirubin glucuronide. Efforts are being made to develop a genetic therapy. ... 

---