Genetic perturbation

Tegner, J., M. K. S. Yeung, J. Hasty, and J. J. Collins. 2003. Reverse engineering gene networks Integrating genetic perturbations with dynamical modeling. Proc Natl Acad Sci USA 100 5944-9. 

Protoplast fnsion is a technique that enables the asexual combination of two complex genomes. However, similarly to conventional breeding, the final result is uncertain because of unpredictable gene transfer with little or no understanding of the specific genetic perturbations (Piddocke Olsson, 2010). As an example of protoplast fusion, the conversion of non-flocculent brewer s yeast to a flocculent one by electrofusion can be cited (Urano, Sahara, Koshino, 1993 Urano, Sato, Sahara, Koshino, 1993). 

OMICS DATA FOR VARIOUS ENVIRONMENTAL AND GENETIC PERTURBATIONS 445... 

---