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Genetic factors, pharmacokinetic

As shown in Figure 15.1, variations in the ethnic response to drugs are related to many interlinking factors. Genetic factors that control both pharmacokinetics and... [Pg.171]

Setting aside issues of compliance and administration errors, the therapeutic response experienced by each patient may be influenced by variations in pharmacokinetics (rate and extent of absorption, distribution, elimination) and pharmacodynamics (physiologic, pathologic, and genetic factors receptor interactions and tolerance). [Pg.116]

The importance of genetic factors in pharmacokinetic and pharmacodynamic processes is becoming more widely recognized, particularly in... [Pg.354]

Genetic factors account for some ADRs due to either altered pharmacokinetics or by altering tissue responsiveness. Altered metabolism of drugs occurs due to differences in hydrolysis, acetylation, and hepatic oxidation of drugs. Altered pharmacodynamic reactions could be either an exaggerated response or a... [Pg.49]

Noetzli M, Guidi M, Ebbing K, Eyer S, Wilhelm L, Michon A et al (2013) Population pharmacokinetic study of memantine Effects of clinical and genetic factors. Clin Pharmacokinet 52 211-223... [Pg.555]

The acetylation of isoniazid and acetylhydrazine are both subject to genetic variability, so the production and detoxication pathways are both influenced by the acetylator phenotype. The hepatotoxicity of isoniazid is therefore dependent on a complex interrelationship between genetic factors and individual variation in the pharmacokinetics of isoniazid. Studies of the pharmacokinetics of acetylhydrazine in human subjects after a dose of isoniazid have revealed that although the peak plasma concentration of acetylhydrazine is higher in rapid acetylators, when the plasma concentration of acetylhydrazine is plotted against time, the area under the curve... [Pg.540]

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See also in sourсe #XX -- [ Pg.123 , Pg.181 ]



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