Genetic causes connective tissue

The special interest is the determination of Fe, as the acceleration of sclerosed process is connected with the accumulation of Fe in this organ. Copper is accumulated in tissues at the genetic caused diseases (Wilson Disease, Hemochromatosis). This is the alteration in elemental ratios (e.g., Cu/Zn), that is the marker of pathological process. 

Connective tissue disorders such as SSc, LE, Sjogren s syndrome, dermatomyositis and RA can be induced by occupational exposure to silica, solvents, and other chemical offenders. An enhanced genetic susceptibility seems to favor these disorders. SSc is the most frequent and best-studied disease. While silica precipitates SSc, the other offenders induce scleroderma-like diseases with different clinical and laboratory findings than with SSc. Taking a careful case history of patients with SSc will help to identify the occupational causes. The best way to prevent this type of connective tissue disease is to minimize the exposure to occupational substances. However, efforts in the form of individual expert decisions have to be made in order to acknowledge these disorders as occupational diseases and provide some social and financial support to patients and reduce the harm caused by these disorders. 

As shown in Fig. 1.1, the integration of pharmacogenomics and systems biology can help elucidate the mechanisms of diseases and drug actions at various levels and connect information between different levels. For example, altered genetic structure may cause malfunctions at the molecular level, which would influence the downstream interactions, pathways, and networks at the cellular level. Such changes may then lead to tissue or organ disorders that are disease phenotypes reflected as... 

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