Genetic ablation

Gogos J.A., Osborne J., Nemes A., Mendelsohn M. and Axel R. (2000). Genetic ablation and restoration of the olfactory topographic map. Cell 103, 609-620. 

Hara, J., Beuckmann, C. T., Nambu, T. et al. (2001). Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30, 345-54. 

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., and Flier, J-S. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature, 366,740-742. 

Washboume P, Thompson PM, Carta M, Costa ET, Mathews JR, Lopez-Bendit6 G, Molnar Z, Becher MW, Valenzuela CF, Partridge LD, Wilson MC. Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nat. Neurosci. 2002 5 19-26. 

Perger B, Leng A, Mura A, Hengerer B, Feldon J (2004) Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inliibition of TNF-syntliesis atterruates MPTP toxicity in mouse striatum. J Nem ochem 89 822—833. 

Antisense oligonucleotides (Tau genetic ablation) c-Jun N-terminal kinase (JNKs) inhibitors Harmine (P-carboline alkaloid)... 

The family of cytokines to which CNTF belongs has pleiotropic effects on multiple tissues, and the use of genetic ablations studies to determine primary or secondary requirements for individual members is often difficult. Mice that are homozygous for an inactivated CNTF gene develop normally, although in late adulthood, they may exhibit a mild loss of motor neurons with resulting... 

Kevin J. Lee, Paula Dietrich and Thomas M. Jessell, Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature, 403 (2000), 734—740. 

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