Generator column method

Water solubility determined by the generator column method by van Haelst et al. [244]. n-Octanol/water partition coefficients determined by Van Haelst et al. using the slow stirring method [245]. 

The experimental approaches are similar to those for solubility, i.e., employing shake flask or generator-column techniques. Concentrations in both the water and octanol phases may be determined after equilibration. Both phases can then be analyzed by the instrumental methods discussed above and the partition coefficient is calculated from the concentration ratio Q/Cw. This is actually the ratio of solute concentration in octanol saturated with water to that in water saturated with octanol. 

Wasik, S. P., Miller, M. M., Tewari, Y. B., May, W. E., Sonnefeld, W. J., DeVoe, H., Zoller, W. H. (1983) Determination of the vapor pressure, aqueous solubihty, and octanol/water partition coefficient of hydrophobic substances by coupled generator column/ liquid chromatographic methods. Res. Rev. 85, 29 42. 

C, generator column/elution method, average values of 6-7 laboratories, OECD 1981) 0.200 (20°C, quoted, Schmidt-Bleek et al. 1982)... 

Reza, J., Trejo, A., Vera-Avila, L.E. (2002) Determination of the temperature dependence of water solubilities of polycyclic aromatic hydrocarbons by a generator column-on-line solid-phase extraction-liquid chromatographic method. Chemosphere 47, 933-945. 

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