Generation and reaction of l- cyclopropylidene -alkylzincs

Generation and reaction of a 1-(cyclopropylidene)alkylzinc synthesis of 1 -[2-(phenylmethyl)cyclopropylidene]pentanenitrile (Structure 39)21 

Caution Carry out ail procedures in a well-ventilated hood, and wear disposable vinyl or latex gloves and chemical-resistant safety goggles. 

Add a solution of p-chlorobenzenesulfonate 1 in THF (2 mL), prepared in a vial under argon. Stir for 6 h at -20°C to prepare cyclopropylidenealkylzinc 38. 

Pour the mixture into 1 N HCI (20 mL). Extract twice with ether and wash the combined organic layers with 5% NaHC03. Dry the extract over MgS04 and evaporate the solvents. 

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