Generally Recognized as Safe Notification

Instead of the formal GRAS affirmation petition, the FDA initiated a new procedure for GRAS ingredients, the GRAS notification. Under the notification process, a 

For many years, chemical manufacturers (makers) and pharmaceutical firms (users) as well as FDA reviewers informally used these FDA food clearance mechanisms to give new drug reviewers (e.g., toxicologists and pharmacologists) a level of comfort about the safety of an excipient contained in a finished pharmaceutical product. 

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FDA (2014) Generally Recognized as Safe (GRAS) Notification for L-Methionine 85% From a Modified Escherichia coli K-12. 

Glycerol esters of rosin are generally recognized as safe substances and approved by several FDA notifications as direct and indirect food additives. They are broadly used in manifold adhesive applications, such as pressure sensitive (PSA) tapes and labels, sealants in flooring and construction, lithographic ink resins, roadmarking resins, bookbinding, as well as other specialty applications. 

Generally recognized as safe (GRAS) notification for glycerol ester of gum rosin.T R. Chemicak, Chnl 2002. 

Foods or Food Additives (Federal Food, Drug and Cosmetic Act) Reasonable certainty of no harm Food Additive Petition— Food and Drug Administration (FDA) must approve that the material is safe Generally Recognized as Safe— Notifier makes safety determination FDA reviews notification... 

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