General Drawbacks of Antibiotic-Loaded Bone Cements

3 General Drawbacks of Antibiotic-Loaded Bone Cements 

When mixing the two components, the polymerization of the liquid monomer starts to yield a solid mass. As the redox reaction is exothermic, a high level of heat is generated, leading to a temperature increase [74]. Due to the thermal behavior of the curing reaction of the bone cement, it is not possible to load the cement with every drug. It is mandatory for the drug to be thermally stable. 

Sometimes this exposure of bone to high temperatures leads to incidences of bone necrosis and tissue damage that could, finally, result in failure of the prosthetic fixation [74]. It has been shown that three factors can affect bony tissue as a consequence of implant fixation using PMMA bone cement [75,76]  

It has been cited by DiPisa et al. [77] that the temperature at the bone-cement interface is a function of  

The use of antibiotic-loaded bone cements requires an exhaustive study of the balance between the importance of the mechanical performance and the need for high doses of drugs to treat infections. 

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