General Analytical Approaches in Metallomics and Metalloproteomics

To identify the biometals and their functions in biological systems, it is desirable to integrate all the related but independently established scientific fields 

The entire protein complement of a given gen- 32,33 ome, that is, the entirety of the proteins that are expressed by the genome 

Study of the proteome of an organism. The term 32,33 is most commonly associated with the use of MS to identify proteins expressed in a given cell type or tissue under a given set of conditions 

The research field dealing with the study of 19 metallomes and their correlations with genomes and proteomes 

The entirety of metal complexes with proteins in 31,34 a sample. Note that this term was originally used in a narrower sense and concerned the proteins with enz5matic functions only 

---