General adaptation syndrome

Along with certain other flavonoids and compounds such as abscisic acid, the jasmonates, and ethylene, it seems that the anthocyanins may function to mitigate the effects of general stress, and are therefore a useful component of the general adaptation syndrome ... 

Leshem, Y.Y. and Kuiper, P.J.C., Is there a GAS (general adaptation syndrome) response to various types of environmental stress Biol Plant., 38, 1, 1996. 

Regulates general adaptation syndrome, water balance, blood pressure, and hormone release. 

The immediate response to stress in a normotensive person may be considered to fall in the alarm reaction stage of what Selye (145,147) has elected to call a general adaptation syndrome, whose manifestations are essentially independent of the specific nature of the stress. The development of clinically sustained hypertension has been considered by him to fall into a second stage of resistance to a prolonged exposure to stress. Similarly, Wolf et al. (166) have presented recently an interesting discussion of hypertension as a reaction pattern to stress. The very readable article by White (164) also stresses the importance of the neurogenic aspects of early hypertension as a major factor that must be dealt with in the management of this disease. 

Selye, H. (1946). The general adaptation syndrome and disease of adaptation. Journal of Clinical Endocrinology and Metabolism 6 117-30. 

The general adaptation syndrome (Selye 1936, 1979) describes three stages of the human response to stressors. In simplified form, this seqnence corresponds to (1) aronsal, (2) resistance, and (3) exhaustion, t The literature on stress and its effects on decision making will not be surveyed here. Books edited by Hamilton and Warbnrton (1979), Svenson and Manle (1993), Driskell and Salas (1996), and Hin et al. (1997) provide a good introdnction to the area... 

Lehmann and coworkers (1989) conducted a three-center, double blind placebo-controlled trial of ( )-kavain (Neuronika ). Of the 56 patients included in the study, four dropped out within the first two weeks of treatment due to reasons unrelated to the study. Of the 52 remaining patients, 21 had a panic syndrome, 17 had generalized anxiety syndrome, 10 disturbance of adaptability, and 4 phobic disturbances. No details were provided in terms of gender. The average age of the total sample was about 40 years. None of the patients were on psychotropic medication for any of the conditions. 

One other area of recent debate in workers compensation cases involves shift-work-maladaption syndrome. These cases usually involve workers who are unable to adapt to working a third shift. Workers asserting these claims usually complain of being unable to adapt their personal sleeping schedules to the late shift, and suffer from continued sleep deprivation. American courts have rejected shift-work-maladaption syndrome as a compensable injury under the workers compensation definitions of injury, and generally hold that harm occasioned by the mere scheduling of hours is not enough to state a claim (53). A worker must show that a specific injury has been caused by a specific workplace condition or job function. 

The degree and extent of the abnormality in thyroid function generally correlates with the severity of the nonthyroidal illness. These conditions are frequently referred to as the euthyroid sick syndrome. It is likely that these changes represent adaptive forms of hypothyroidism that serve to reduce the availability of thyroid hormones to lessen the impact of the nonthyroidal Ulness. ... 

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