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Gene silencing mechanism

RNAi and ribozymes represent two additional approaches to gene silencing/down-regulation with therapeutic potential. RNAi is an innate cellular process that achieves silencing of selected genes via an anti-sense mechanism. It shares many characteristics with the antisense-based approach described above, but also some important differences, e.g. in the exact mechanism by which the antisense effect is achieved. [Pg.451]

DAWSON, W.O., Gene silencing and virus resistance a common mechanism, Trends Plant Sci., 1996,1,107-108. [Pg.195]

De Smet C, Lurquin C, Lethe B, Martelange V, Boon T (1999) DNA methylation is the primary silencing mechanism for a set of germ line- and mmor-specific genes with a CpG-rich promoter. Mol Cell Biol 19 7327-7335... [Pg.423]

Meister G, Tuschl T (2004) Mechanisms of gene silencing hy double-stranded RNA. Nature 431 343-349... [Pg.70]


See other pages where Gene silencing mechanism is mentioned: [Pg.352]    [Pg.360]    [Pg.66]    [Pg.1869]    [Pg.140]    [Pg.321]    [Pg.629]    [Pg.694]    [Pg.956]    [Pg.321]    [Pg.935]    [Pg.141]    [Pg.141]    [Pg.469]    [Pg.171]    [Pg.112]    [Pg.10]    [Pg.352]    [Pg.360]    [Pg.66]    [Pg.1869]    [Pg.140]    [Pg.321]    [Pg.629]    [Pg.694]    [Pg.956]    [Pg.321]    [Pg.935]    [Pg.141]    [Pg.141]    [Pg.469]    [Pg.171]    [Pg.112]    [Pg.10]    [Pg.17]    [Pg.117]    [Pg.190]    [Pg.43]    [Pg.67]    [Pg.360]    [Pg.402]    [Pg.298]    [Pg.304]    [Pg.323]    [Pg.331]    [Pg.123]    [Pg.14]    [Pg.22]    [Pg.40]    [Pg.189]    [Pg.1888]    [Pg.150]    [Pg.423]    [Pg.424]    [Pg.44]    [Pg.52]    [Pg.191]    [Pg.193]    [Pg.212]    [Pg.466]    [Pg.159]   
See also in sourсe #XX -- [ Pg.424 ]




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