Gene mandelate pathway

Scheme 2.2.1.1 Mandelate pathway benzoylformate decarboxylase (BFD), encoded by the gene md/C, catalyzes the conversion of benzoylformate 3 to benzaldehyde 4 and carbon dioxide.

The mandelate and jS-ketoadipate pathways serve as an example of gene duplication, as there is strong evidence pointing to the former evolving from the latter. Evolution of mandelate racemase from muconate lactonizing enzyme points to the relevance of the enzyme mechanism for catalytic reactivity. 

Example of Gene Duplication Mandelate and a-Ketoadipate Pathways... 

The mandelate and jS-ketoadipate pathways are a good example of gene duplication, with strong evidence of the former evolving from the latter the congruence of MR and MLE, (S)-ManDH and benzoate dihydrodiol dehydrogenase, and possibly benzoyl formate decarboxylase and protocatechuate decarboxylase. 

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