Gene expression class discovery

Golub TR et al. Molecular classification of cancer class discovery and class prediction by gene expression monitoring. Science 1999 286 531-537. 

Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. Molecular classification of cancer class discovery and class prediction by gene expression monitoring. Science 1999 286 531-537. 

Gene signatures can be found using three main computational approaches DE, class assignment and prediction based on expression, and class discovery based on expression. 

Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., et al. (1999) Molecular classification of cancer Class discovery and class prediction by gene expression monitoring. Science 286, 531-537. 

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