Gene-Drug Interaction

Tab. 3.4 Structure of data to perform stratified analysis to assess gene-drug interaction...

Table 4.3 provides examples of transporter polymorphisms that have had an effect on certain substrates in vitro or in vivo that have explained interindividual variability toward these drugs in clinical pharmacology or have not. It should be mentioned that just because a polymorphism has no effect on a substrate drug in the clinic, a potential gene-drug interaction could not be found following treatment with another substrate drug. 

Another feature of this volume is the emphasis on the examinations of gene-drug interactions, that is, how drugs act and how they are processed in the human body, including drug absorption, distribution, metabolism, and excretion. Biomarkers and molecules... 

Regulation of drug Detoxification genes Drug interactions... 

Suzuki, O.T., Frick, A., Parks, B.B., Trask, O.J., Jr., Butz, N., Steffy, B., Chan, E., ScoviUe, D.K., Healy, E., Benton, C., McQuaid, P.E., Thomas, R.S., Wiltshire, T., 2014. A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes. Front Genet 5, 272. 

While generally not of major concern, omeprazole may inhibit the metabolism of warfarin, diazepam, and phenytoin lansoprazole may decrease theophylline concentrations. Drug interactions with omeprazole are of particular concern in patients who are considered slow metabolizers, as are approximately 3% of the Caucasian population. Unfortunately, it is unclear which patients have the polymorphic gene variation that makes them slow metabolizers.17 The metabolism of esomeprazole may also be altered in patients with this polymorphic gene variation. Patients on potentially interacting drugs should be monitored for development of drug-related problems. 

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