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Gene delivery condensation

Singh R, Pantarotto D, McCarthy D, Chaloin O, Hoebeke J, Partidos CD, Briand JP, Prato M, Bianco A, Kostarelos K (2005) Binding and condensation of plasmid DNA onto functionalized carbon nanotubes Toward the construction of nanotube-based gene delivery vectors. J. Am. Chem. Soc. 127 4388 4396. [Pg.49]

The library was screened for DNA-complexing materials as well as gene delivery vectors, revealing several new materials that were able to condense DNA... [Pg.9]

Successful gene delivery by use of cationic liposomes requires the following conditions (134) (1) condensation of DNA into the complex and its protection from degradation by intracellular nucleases (2) adhesion of DNA-lipid complex onto the cellular surface (3) complex internalization (4) fusion of an internalized DNA-cationic liposome complex with the endosome membrane (5) escape of DNA from the endosome (6) entry of DNA into the nucleus followed by gene expression. [Pg.349]

Chronologically, this is the second family of cationic lipids that were employed for gene delivery. The pioneering work was presented by Behr et al. (1989), who had proposed to take advantage of DNA condensing property of a naturally occurring polyamine, such as spermine. Indeed, during cell division,... [Pg.276]

Cationic and non-condensing polymer-based gene delivery... [Pg.336]

CATIONIC AND NON-CONDENSING POLYMER-BASED GENE DELIVERY 337... [Pg.337]

CATIONIC AND NON-CONDENSING POLYJvIER-BASED GENE DELIVERY... [Pg.339]

Figure 17.5 Chemical structures of non-condensing polymers used as gene delivery vectors. Figure 17.5 Chemical structures of non-condensing polymers used as gene delivery vectors.
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See also in sourсe #XX -- [ Pg.243 ]



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Gene delivery

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