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Gene Cancer cell, Reversion

Besides the mouse lymphoma cells, the R123 accumulation was also studied in the human breast cancer HTB-26 cells in the presence of carotenoids. The R123 accumulation could not be modified in these cells after carotenoid treatment (Table 2). Because these cancer cells do not contain a MDR efflux pump because the cells have only MDR-related protein (MRP). It is concluded that some carotenoids exert their MDR reversing effect in the human MDR-1 gene-transfected mouse lymphoma cells. However, the same carotenoids did not modify the drug accumulation in the drug-sensitive human breast carcinoma cells (data not shown). It is interesting... [Pg.140]

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